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Old 10-19-2009, 04:26 AM   #1
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The Future of Nutrient Delivery - Liqua-Vade

Dear PHF Members,

Primordial Performance is proud to present their new Liqua-Vade™ nutrient delivery technology. Liqua-Vade is literally a liquid nutrient invasion.



Liqua-Vade technology is based off a pharmaceutical drug delivery technology known as a Self Emulsifying Drug Delivery System (SEDDS). (1-15) This technology was designed to enhance absorption of poorly water soluble compounds. This includes various hormones, flavonoids, and fat soluble vitamins (carotenoids, vitamin E, CoEnzyme Q-10, ect)

The technology enhances delivery of poorly soluble compounds by dissolving and making them highly dispersed in the digestive track. To see exactly how Liqua-Vade solubilizes poorly water soluble compounds, visit this page – Liqua-Vade



Here are a few clinical trials of Liqua-Vade technology (SEDDS) enhancing delivery of poorly water soluble nutrients –

Poorly water soluble vitamin (CoQ10) -


Steroid hormone -


Isoflavone from kudzu root -


Flavone from silymarin (milk thistle extract) -


I’d like to thank you for reading this special announcement from Primordial Performance.

Yours in health & fitness,

Jeff Jarvis
Primordial Performance

Questions?

Phone – 1-800-568-2924
Email - info@primordialperformance.com
Visit - Primordial Performance


References –

1. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs.
Porter C, et al
Nat Rev Drug Discov 2007 Mar;6(3):231-48

2. Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine.
Odeberg et al.
Eur J Pharm Sci. 2003 Dec;20(4-5):375-82

3. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
Constantinides PP et al.
Pharm Res. 1995 Nov;12(11):1561-72

4. Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria Lobata isoflavone.
Cui et al.
Drug Dev Ind Pharm. 2005 May;31(4-5):349-56.

5. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs.
Gao P, et al.
Expert Opin Drug Deliv. 2006 Jan;3(1):97-110

6. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems.
Balakrishnan P, et al.
Int J Pharm. 2009 Jun 5;374(1-2):66-72.

7. Clinical studies with oral lipid based formulations of poorly soluble compounds.
Fatouros DG, et al
Ther Clin Risk Manag. 2007 Aug;3(4):591-604

8. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Nesliham et al.
Biomed Pharmacother. 2004 Apr;58(3):173-82. Review.

9. Formulation of lipid-based delivery systems for oral administration: Materials, methods, and strategies
Pouton CW et al.
Adv Drug Deliv Rev. 2008 Mar 17;60(6):625-37. Epub 2007 Nov 4

10. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.
Susan et al.
Pharm Res. 1992 Jan;9(1):87-93.

11. Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water soluble drug
Greg A et al.
J Pharm Sci. 2005 Mar;94(3):481-92.

12. Cyclosporin nanoparticulate lipospheres for oral absorption
Tania et al.
J Pharm Sci. 2004 May;93(5):1264-70

13. Self-Emulsifying Drug Delivery Systems: Strategy for improving oral delivery of poorly water soluble drugs.
Jing et al.
Current Drug Therapy, 2007, 2, 85-93

14. Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin.
Quan DQ, et al.
Chem Pharm Bull (Tokyo). 2007 May;55(5):800-3

15. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
Wu W, et al
2006 Jul;63(3):288-94. Epub 2006 Mar 9









There are multiple ways to dose Liqua-Vade –

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Old 10-20-2009, 11:36 AM   #2
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Quote:
Originally Posted by Maxgolf View Post
Dear PHF Members,

Primordial Performance is proud to present their new Liqua-Vade™ nutrient delivery technology. Liqua-Vade is literally a liquid nutrient invasion.



Liqua-Vade technology is based off a pharmaceutical drug delivery technology known as a Self Emulsifying Drug Delivery System (SEDDS). (1-15) This technology was designed to enhance absorption of poorly water soluble compounds. This includes various hormones, flavonoids, and fat soluble vitamins (carotenoids, vitamin E, CoEnzyme Q-10, ect)

The technology enhances delivery of poorly soluble compounds by dissolving and making them highly dispersed in the digestive track. To see exactly how Liqua-Vade solubilizes poorly water soluble compounds, visit this page – Liqua-Vade



Here are a few clinical trials of Liqua-Vade technology (SEDDS) enhancing delivery of poorly water soluble nutrients –

Poorly water soluble vitamin (CoQ10) -


Steroid hormone -


Isoflavone from kudzu root -


Flavone from silymarin (milk thistle extract) -


I’d like to thank you for reading this special announcement from Primordial Performance.

Yours in health & fitness,

Jeff Jarvis
Primordial Performance

Questions?

Phone – 1-800-568-2924
Email - info@primordialperformance.com
Visit - Primordial Performance


References –

1. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs.
Porter C, et al
Nat Rev Drug Discov 2007 Mar;6(3):231-48

2. Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine.
Odeberg et al.
Eur J Pharm Sci. 2003 Dec;20(4-5):375-82

3. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
Constantinides PP et al.
Pharm Res. 1995 Nov;12(11):1561-72

4. Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria Lobata isoflavone.
Cui et al.
Drug Dev Ind Pharm. 2005 May;31(4-5):349-56.

5. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs.
Gao P, et al.
Expert Opin Drug Deliv. 2006 Jan;3(1):97-110

6. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems.
Balakrishnan P, et al.
Int J Pharm. 2009 Jun 5;374(1-2):66-72.

7. Clinical studies with oral lipid based formulations of poorly soluble compounds.
Fatouros DG, et al
Ther Clin Risk Manag. 2007 Aug;3(4):591-604

8. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Nesliham et al.
Biomed Pharmacother. 2004 Apr;58(3):173-82. Review.

9. Formulation of lipid-based delivery systems for oral administration: Materials, methods, and strategies
Pouton CW et al.
Adv Drug Deliv Rev. 2008 Mar 17;60(6):625-37. Epub 2007 Nov 4

10. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.
Susan et al.
Pharm Res. 1992 Jan;9(1):87-93.

11. Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water soluble drug
Greg A et al.
J Pharm Sci. 2005 Mar;94(3):481-92.

12. Cyclosporin nanoparticulate lipospheres for oral absorption
Tania et al.
J Pharm Sci. 2004 May;93(5):1264-70

13. Self-Emulsifying Drug Delivery Systems: Strategy for improving oral delivery of poorly water soluble drugs.
Jing et al.
Current Drug Therapy, 2007, 2, 85-93

14. Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin.
Quan DQ, et al.
Chem Pharm Bull (Tokyo). 2007 May;55(5):800-3

15. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
Wu W, et al
2006 Jul;63(3):288-94. Epub 2006 Mar 9









There are multiple ways to dose Liqua-Vade –

I like the worm shot myself


and YES I am using the first version out there

Thanks Primordial Performance
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Old 10-20-2009, 12:36 PM   #3
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Too bad I got 2 bottles of the rub in application right here...

By the way it looks sweet.
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Old 10-20-2009, 09:31 PM   #4
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Looks tasty lol
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Old 10-22-2009, 12:07 AM   #5
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whats it taste like ;d
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Old 10-23-2009, 11:50 AM   #6
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whats it taste like ;d
it is a cherry flavor
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Old 11-11-2009, 01:28 PM   #7
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So what would you guys say if i told you we have Dermacrine and 1-T about ready to come out in Liqua-Vade
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Old 11-12-2009, 06:30 PM   #8
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i would say get outta town
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Old 11-12-2009, 07:29 PM   #9
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I would say I will be your ginni pig
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Old 11-12-2009, 08:58 PM   #10
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I would say I wuz ginni piggin SA on cycle at the moment
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Old 11-13-2009, 07:01 AM   #11
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Primoridial Performance are cool guys.

Will that work with curcumin as well? I guess it should....
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Old 11-13-2009, 08:44 AM   #12
WHY SO SERIOUS???
 
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I would say I will be your ginni pig
this^^^^^^^
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Old 11-13-2009, 11:34 AM   #13
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this^^^^^^^
this again^^^^^^^
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Old 12-13-2009, 09:35 PM   #14
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We now have Tren Liqua-Vade available for a short time. Only 500 bottles will be produced.
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