awesome. I like reading this stuff but sometimes I have no clue what they are talking about.

Sundrk, if you cannot get a FT feel free to use me as a back up as well. I have access to a fairly large collection of journals.

I have accounts at 2 different Universities, neither of which give me access to these 3 papers:

L. Shah, Neeral, Isabel Zacharias, Urmila Khettry, Nezam Afdhal, and Fredric D. Gordon.” Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases.” Clinical Gastroenterology and Hepatology. 6.2 (2008): 255-258.

Recent advances in the development of selective androgen receptor modulators.
Expert Opin Ther Pat. 2009 Sep;19(9):1239-58.
Zhang X, Lanter JC, Sui Z.

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery.
Expert Opin Investig Drugs. 2006 Apr;15(4):377-87.
Segal S, Narayanan R, Dalton JT.

Originally Posted by henryv

The Dienol-Benzene Rearrangement.1 Some Chemistry of 1,4-Androstadiene-3,17-dione
Margaret Jevnik Gentles, Jane B. Moss, Hershel L. Herzog, E. B. Hershberg
J. Am. Chem. Soc., 1958, 80 (14), pp 3702–3705
DOI: 10.1021/ja01547a058
Publication Date: July 1958

As mentioned here.

Originally Posted by henryv

ingentaconnect The general dienol : benzene rearrangement of ring A of the stero...

sent those to you

Do you guys have access to this one?

Copyright © 2000 Academic Press. All rights reserved.
Permissions & Reprints

Regular Article
Glutamate-loading Stimulates Metabolic Flux and Improves Cell Recovery Following Chemical Hypoxia in Isolated Cardiomyocyte*1

This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.


Helen Williams, Nicola King, Elinor J. Griffiths and M. -Saadeh Suleiman

Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UK

Received 9 May 2001; accepted 11 September 2001. ; Available online 26 February 2002.

Abstract
The amino acid glutamate is used in cardioplegic solutions, yet evidence is conflicting as to whether or not exogenous glutamate is indeed cardioprotective. This controversy may be because increasing extracellular glutamate does not necessarily lead to an increase in intracellular glutamate. In this study we aimed to determine whether isolation of myocytes in the presence of glutamate resulted in glutamate-loading of the cells, and, if so, whether such loading protected myocytes from simulated (chemical) hypoxia. Single ventricular myocytes were isolated from rat hearts in the presence and absence of 6.4 m glutamate. Levels of glutamate and ATP were determined using HPLC, and NADH/NAD+was determined from cell autofluorescence. Chemical hypoxia was induced by superfusion with a solution containing 2.5 m cyanide and no glucose. Intracellular [Ca2+] was measured by loading cells with indo-1, and cell length was measured using an edge-tracking device. Isolation of myocytes in the presence of glutamate resulted in increased intracellular glutamate levels compared with cells isolated in the absence of glutamate, 1324±108 v 948±124 pmol/mg protein, respectively (P<0.05). Cells loaded with glutamate showed increased NADH/NAD+, (0.384±0.032v 0.281±0.029, P<0.05) and greater ATP levels (36.031±1.633 nmol/mg protein v 19.279±3.327 nmol/mg protein, P<0.005) compared to control cells. When subjected to chemical hypoxia, cells underwent rigor-contracture at various timepoints, and were then reperfused following 5 min in rigor. Cells loaded with glutamate showed better recovery of diastolic [Ca2+], Ca2+transient amplitude, and improved contractile function compared with cells isolated in absence of glutamate. This study demonstrates an efficient method for loading myocytes with glutamate during cell isolation, and myocytes loaded with glutamate showed increased metabolic flux, as indexed by a higher NADH/NAD+and ATP content. Myocytes also exhibited better recovery from chemical hypoxia in terms of both Ca2+handling and cell contraction.

Author Keywords: Cardiomyocytes; Chemical hypoxia; Glutamate; Amino acid metabolism; Intracellular calcium; Contractile function; NADH.

*1 Please address all correspondence to: Dr M.-S. Suleiman, Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW. Tel: 0117-9283519; Fax: 0117-9299737;E-mail: M.S.Suleiman@bristol.ac.uk

This one too please...


J Steroid Biochem. 1990 Aug 28;36(6):603-8.

Ethanol-induced inhibition of testosterone biosynthesis in rat Leydig cells: central role of mitochondrial NADH redox state.
Orpana AK, Orava MM, Vihko RK, Härkönen M, Eriksson CJ.

Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.

Abstract
The mechanisms by which ethanol (EtOH) inhibits the human chorionic gonadotropin (hCG)-stimulated testosterone synthesis was studied in isolated rat Leydig cells in vitro. EtOH inhibited steroidogenesis, but this inhibition was reversed by L-glutamate (Glu) and an uncoupler of the oxidative phosphorylation, 2,4-dinitrophenol (DNP). The mechanism of EtOH-induced inhibition was studied by measuring steroidogenic precursors and comparing them with the cytosolic and mitochondrial NADH redox states during uncoupling or in the presence of Glu. DNP had a dual effect. Low concentrations abolished the EtOH-induced inhibition of progesterone to testosterone formation suggesting that the inhibitory step was at or before progesterone formation. A large concentration led to an overall decrease in steroidogenesis indicating toxic effects on steroidogenesis. The mitochondrial NADH/NAD+ ratio, measured as the 3-hydroxybutyrate/acetoacetate ratio, decreased simultaneously when steroidogenesis was stimulated, either during uncoupling or in the presence of Glu, whereas cytosolic NADH/NAD+ ratio, measured as lactate/pyruvate ratio showed no response. These results demonstrate that the rise in the mitochondrial NADH/NAD+ ratio rather than in the cytosolic one is connected with the inhibition of testosterone synthesis by EtOH in isolated Leydig cells. The EtOH-induced high mitochondrial NADH/NAD+ ratio may deplete mitochondrial oxalacetate concentrations. This can decrease the activity of several transport shuttles and interrupt the flow of mitochondrial citrate into the smooth endoplasmic reticulum, which then reflects to decreased rate of steroidogenesis in the presence of ethanol.

PMID: 2214777 [PubMed - indexed for MEDLINE]

lol I cant get shit I want today, one moar:


Nutrition
Volume 18, Issue 2, February 2002, Pages 130-133


--------------------------------------------------------------------------------
doi:10.1016/S0899-9007(01)00767-5 | How to Cite or Link Using DOI
Copyright © 2002 Elsevier Science Inc. All rights reserved.
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Fourth Oxford glutamine workshop
Relation between glutamine, branched-chain amino acids, and protein metabolism1 , *1

This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.


Milan Hole ek MDa, ,

a Department of Physiology, Charles University School of Medicine, Hradec Králové, Czech Republic


Available online 6 February 2002.

Abstract
The branched-chain amino acids (BCAAs; valine, isoleucine, and leucine) are the major nitrogen source for glutamine and alanine synthesis in muscle. Synthesis of glutamine, alanine, and BCAA use is activated in critical illnesses such as in sepsis, cancer, and trauma. The use of glutamine often exceeds its synthesis, resulting in the lack of glutamine in plasma and tissues. In critical illness, resynthesis of BCAA from branched-chain keto acids is activated, particularly in hepatic tissue. The BCAA released to circulation may be used for protein synthesis or synthesis of alanine and glutamine. Glutamine and/or alanine infusion has an inhibitory effect on the breakdown of body proteins and decreases BCAA catabolism in postabsorptive control, endotoxemic, and irradiated rats. Decreased protein breakdown also was observed when glutamine synthesis was activated by ammonia infusion. In conclusion some favorable effects of BCAA supply can be explained by its role in the synthesis of glutamine and some positive effects of glutamine exogenous supply can be explained by its effect on metabolism of BCAA.

Author Keywords: branched-chain amino acids; glutamine; alanine; protein metabolism

edit: taken down

Originally Posted by Strive6

Couldn't get the second one, but I got the other two. I'll be taking these down by tomorrow just to let you know

Thanks. Actually got the third. You're welcome to take them down now.

Originally Posted by henryv

Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer

http://rapidshare.com/files/452411945/Res_Analogs.pdf

Originally Posted by henryv

It was pretty interesting (though mostly way above my level of understanding). All the analogues are synthetic though, so I guess unless they manage to find some naturally occurring analogues that have the same properties (like increased aromatase inhibition) we can't expect to see them in a supp anytime soon (due to DSHEA legislation).

Do you know how the IC50 values on the analogs compare to things like letro and aromasin?

Cool, was just curious as to whether they would be too strong or comparable. Appear to be similar though.

Can someone get me the full text of these three articles?

Much appreciated.

Can you get the full article on facile Synthesis Of crysin Derivatives with promising Activities as aromatase inhibitors haven't learn't how to post links yet

Originally Posted by henryv

ScienceDirect - Yen &#x0026; Jaffe's Reproductive Endocrinology (Sixth Edition) : The Synthesis and Metabolism of Steroid Hormones

Good read. PM me your email??

Originally Posted by henryv

ANABOLIC-ANDROGENIC ACTIVITY OF A-RING MODIFIED ANDROSTANE DERIVATIVES. -- Nutting et al. 53 (4): 635 -- Acta Endocrinologica

It's no surprise the 1-methyl derivative exerted the highest Q ratio. The 1-methyl group seems to be consistent in its androgenic reducing and anabolic activity increasing behavior; At least in the androstane steroids. It's one of the few substituents that's the least bit predictable.