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Prohormones Today (Current Compound Descriptions)


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#1 Holden Caulfield

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Posted 08 August 2009 - 03:40 PM

Prohormones - A Comprehensive Guide Prohormones Article - Updated 27/07/09
By Reggie Johal

Reggie Johal is a published author on nutrition and supplements, as well as international athlete and coach to many sportsmen and women.


Prohormones - A Comprehensive Guide to Prohormones - Updated



Halodrol- 50 (4-chloro-17a-methyl-1,4-diene-3,17 diol)

Halodrol-50 was introduced to the bodybuilding world by Gaspari Nutrition and is a prosteroid of Turinabol, the banned East German designer steroid. This means it converts to Turinabol once ingested. Although Halodrol is no longer available, there are generic equivalents today such as Competitive Edge Labs H-Drol or EST Hemadrol. The typical dose for products such as H-Drol is 50mg a day, which equates to one tablet daily.

Effects: Solid gains in muscle and strength, often taken while dieting to aid preservation of muscle mass.

Side effects: Considered stressful on the liver and can raise blood pressure somewhat in users.

Havoc/Epistane (2a-3a-epithio-17a-methyl-5a-androstan-17b-ol)

RPN's product Havoc and IBE's Epistane were introduced at practically the same time and considered interchangeable by many. However, it should be noted that even when two products are identical, users can experience different effects depending on the quality of the isomer, manufacturing process and so on.

With Havoc and Epistane they are chemically very slightly different 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol 2 (Havoc), and 2, 3a-epithio-17a-methyletioallo cholan-17b-ol (Epistane). Dosages are usually in the 20-50mg range.

Effects: Good for promoting solid, lean muscle gains with a concomitant reduction in estrogen leading to a drier physique, and significant strength gains. This will contribute to the vascularity users typically report. Havoc and Epistane are also sometimes used purely to combat gynecomastia as they act in the body as an anti-estrogen, so that endogenous testosterone levels are less suppressed by this compound than other prohormones.

Side effects: Less hepatoxic and damaging to lipid levels than other orals but the usual androgenic side effects associated with prohormones remain a possibility.

Pheraplex (17a-methyl-etioallocholan-2-ene-17b-ol)

Pheraplex was a brand name of the supplement company Anabolic Xtreme (AX). This product is also sold by Competitive Edge Labs as P-Plex as well as Phera-Vol by EST. Typically dosed at 20-30mg a day.

Effects: Gains with this product tend to be of a 'wet' nature, in other words, you will see some weight gain due to water retention. Given this, P-Plex is often used to gain mass quickly for users.

Side effects: It is a risk for anyone with gynecomastia based on user feedback and is considered to be both hepatoxic and damaging to lipid levels.

Methoxy-TST (17b-methoxytrienosterone)

This product was brought to the market by Bioscience Technologies and is usually dosed at 6-12mg to see results.

Effects: Not a strong bulking product unless doses are pushed high despite its androgenic profile. In this respect it is not dissimilar to AAS such as Masteron and Proviron which are not efficient for bulking.

Side effects: Androgenic side effects such as hair loss are reported quite frequently by users if this product, and many users report a damaging effect on libido.

Ergomax LMG (17-methyl-delta-2-etioallocholane & 17-methyl-delta-3-etioallocholane)

Introduced by ALRI, this is another 'wet' prohormone dosed at 20-40mg usually.

Effects: This compound is quite similar to Pheraplex so is useful for someone wanting to gain mass quickly even if the visual appearance of this will not be the best.

Side effects: Can cause gynecomastia making use of an estrogen blocker a wise option, and has a detrimental effect on liver and lipid values, meaning cycles should be kept short.

M-1,4ADD (17a-methyl-1,4-androstadiene-3,17diol)

M-1,4ADD has recently been reintroduced by Competitive Edge Labs among others and is from the old school of prohormones – a classic wet bulker which converts after ingestion into Methandrostenolone, better known as Dianabol.

Effects: This is a good choice for rapid mass and strength gains but the gains will tend to cause smoothness due to the water retention it causes.

Side effects: This compound can promote both androgenic and estrogenic side effects so anyone with a predisposition to hair loss or gynecomastia should probably avoid this.

11-Oxo (andrenosterone, 11-oxo-androstenedione)

11-Oxo was introduced by Ergopharm, whose owner Patrick Arnold first brought prohormones to the bodybuilding world. 11-Oxo is well regarded for its ability to lower cortisol levels. It is dosed at between 300-600mg a day with 450mg typical.

Effects: Used mainly as a recomposition agent and to promote fat loss, 11-OXO is also a good choice for individuals looking to stack one prohormone with another.

Side effects: Although it can cause the same side effects as other prohormones, it is considered very mild in this regard so a good choice for people looking to diet with minimal side effects.

Propadrol (12-ethyl-3-methoxy-gona-diene)

This was developed by EST Nutrition and is usually dosed at 90mg a day.

Effects: Noted to be good for reducing body fat and for promoting rapid strength and muscle gains.

Side effects: Relatively mild with this compound, although those who worry about gyno or androgenic side effects should exercise caution. Tends to be expensive!

Methoxy-TRN (17b-Methoxy-Trienbolone)

ALRI introduced this compound and it is dosed at 3-6mg by most users.

Effects: Reviews are mixed on this product but those who do like it often claim very good muscle and strength gains allied to a reduction in body fat.

Side effects: Being both quite androgenic and estrogenic it should be used with caution and remedies to combat hair loss and gyno are worth considering.

Max LMG (13-ethyl-3methoxygona-2, 5(10)-dien-17-one)

Yet another product by ALRI. This one is usually dosed at around 100mg a day.

Effects: Max LMG can cause rapid gains in bulk of a wet nature due to its progestogenic nature. Great for those needing fast weight gain and unconcerned about looking smooth or fat.

Side effects: One to avoid for anyone worried about a quality looking physique, gynecomastia, or hair loss. This is also very expensive!

3-AD (2-androstenol acetate)

Anabolic Xtreme formulated this product and brought it on to the bodybuilding market. Usually dosed at around 4-6 capsules a day, 3-AD contains various other nutrients, but the active prohormone is 2-androstenol acetate.

Effects: Effective overall mass gainer. Gains are a little wet, but not too bad for those worried about estrogen.

Side effects: It is not the worst, but estrogenic and androgenic side effects remain a possibility.

Superdrol (Methasteron)

Superdrol was introduced by Designer Supplements, the old name for Driven Sports, and earned a reputation as a very powerful product. Although it is no longer made by Driven Sports, Competitive Edge Labs currently produce a clone called M-Drol.

Effects: Good lean mass gainer with effective repartitioning effects.

Side Effects: Notably hepatoxic, and androgenic. Can aggravate hairloss if prone to male pattern baldness. Highly recommended to stack this product with a product from our Liver Support category to help support healthy liver function.

Dymethazine - (2,17-dimethyl-5-androstan-17-ol-3,3'-azine)

Dymethazine, also known as Dimethazine, is a DHT derived compound with an interesting chemical structure. It is essentially a double bonded Superdrol, with an Azine bridge. A relatively recent introduction to the prohormone world by I Force Nutrition, Dymethazine is a product that has attracted a great deal of interest given its unique chemical structure.

Effects: Users of this compound are reporting results that are qualitatively similar to dry, non-aromatizing products such as Epistane. Dymethazine users have typically reported big muscle and strength gains. Based on feedback to date Dymethazine looks to be the strongest product available on the market today.

Side Effects: Although not having any estrogenic action, Dymethazine use poses the same issue of liver toxicity and androgenic effects as other prohormones.

The One – (17a-methyl-etioallocholan-17b-ol-3-hydroxyimine)

The One was developed by Applied Nutriceuticals and is a prohormone of Dihydrotestosterone.

Effects – Being a prohormone to DHT, The One can be expected to be notably androgenic, resulting in dry, muscle gains with an absence of water retention and solid gains in strength.

Side Effects – Being that it converts into DHT, The One can be expected to be tough on the hairline as DHT is the hormone most responsible for hair loss. As it does not convert to estrogen or progesterone, side effects related to those should not be an issue. Liver toxicity would remain a concern though and it would be a good idea to take this product with something to support health liver function.

1,4 AD Bold 200 – (1, 4 Androstadiene-3, 17- Dione 200mg)

Made by I Force Nutrition, 1,4 Bold 200 is a precursor to the compound Boldenone (Equipoise) which has a very long history of use in bodybuilding circles and is highly regarded for its ability to increase muscle mass with minimal side effects.

Effects - Bold 200 has the advantage of being non-methylated making it a first choice along with Furazadrol, or Finavol for newcomers to the prohormone field. Users typically can expect to notice improved muscle gains which will come steadily and less dramatically than other compounds, as well as an improved appetite and increase in vascularity.

Side Effects – There is a comparatively low risk of both androgenic or estrogenic side effects and being non-methylated makes it an ideal choice for those concerned with liver health. It also makes it ideal for use in a stack with stronger, methylated prohormones such as dymethazine.

Finavol – ( Estra-4,9-diene-3,17-dione)

Sold by a number of different brands, including Competitive Edge Labs (X-Tren), and Chaparral Labs (Trenavol) Finavol is APS Nutrition’s version of this compound. This product has Nandrolone as a target hormone and is non-methylated, making it safer on the liver and an excellent choice as part of a prohormone stack.

Effects – Finavol is well suited to athletes looking for muscle gains with an increase in vascularity and strength that are compared as qualitatively similar to the compound Trenbolone.

Side Effects – Nandrolone precursors can negatively impact upon libido in some people.

Furazadrol – (5a-androstano(2,3-c) furazan-17b-tetrahydropyranol ether - 50mg)

Furazadrol was developed by Axis Labs as an alternative to methylated prohormones such as Havoc or Dymethazine. As a non-methylated compound it will appeal on the grounds of being very safe and is often used by beginners new to prohormones either alone or in a stack with Bold 200.

Effects – Furazadrol has a high anabolic to androgenic ration meaning muscle gains with low risk of androgenic side effects. It does not convert to estrogen meaning gains will be lean in nature, with an absence of water retention.

Side Effects – Although the risk of side effects is low, it is usually required to be dosed in dosages of 200-400mg a day making it quite expensive. Given its otherwise favourable profile it makes an excellent choice for someone looking to stack with another prohormone.

Edited by Holden Caulfield, 09 December 2009 - 03:42 PM.

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i may sound like i know a thing or two but im probably talking out of my ass


#2 Holden Caulfield

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Posted 08 August 2009 - 03:46 PM

...continued


Technical Definition


Prohormones are compounds which are converted via an enzymatic process to anabolic hormones in the body. As such they will cause similar effects in the body to anabolic steroids, inducing rapid muscle and strength gains, but of a lesser magnitude than anabolic steroids, due to the rate limiting effect caused by the enzyme conversion. However, this technical definition is nowadays considered out of date due to the innovation displayed in the supplement industry since the introduction of the very first prohormone, androstenedione. Today the term prohormones is used to cover not just precursors to steroid hormones but also covers compounds which are active in their own right and which require no conversion to a different hormone to engender any anabolic effects. For the sake of simplicty, in this article the term 'prohormone' will cover all products which work via a hormonal mechanism to cause anabolic effects, and not just those which convert from one compound into another after ingestion.


First Base


Prohormones were introduced on to the supplement world in 1996 by reknowned US chemist Patrick Arnold who developed the supplement androstenedione and unleashed it on an unsuspecting public.

Androstenedione certainly created a buzz in the sports world and is heavily linked in the popular press with baseball greats such as Mark McGwire whose use of the supplement was brought to light as he chased the baseball home run record in 1998. In breaking the record that year McGwire brought notoriety both to that sport and captured the attention of law makers in the United States.

Androstenedione was quickly followed by a number of other supplements - androstenediol, norandrostenediol, 1-4-androstadienedione and 5 alpha androstenediol to name just a few. These all had different effects, some being converted to testosterone in the body, while others were converted in the body to anabolic hormones such as nandrolone, boldenone, and dihydrotestosterone (DHT). We still see precursors to some of these products on the bodybuilding market today, such as I Force Nutrition's BOLD 200 product which is a precursor to Boldenone which is the generic term for the steroid Equipoise.

After some time, Patrick Arnold's company Ergopharm introduced the prohormone 1-AD, which converted into a hormone called 1-testosterone. This was the first prohormone considered to be of comparable effectiveness to illegal steroids such as Winstrol or Primobolan. In fact at the time of its introduction much was made of the fact that it was qualitatively similar to the steroid Trenbolone Acetate.

With the introduction of 1-AD, prohormones had clearly progressed in leaps and bounds since the introduction of androstenedione (widely considered within bodybuilding to be pretty worthless by that time). With the introduction of 1-AD, the prohormone market changed dramatically. A number of supplement companies, aware that the process of enzymatic conversion meant that prohormones were weaker than taking an equivalent amount of the target hormone they converted into, decided to market products such as 1-testosterone (the hormone which 1-AD would convert to) and, eventually, the now notorious methyl-1-testosterone (M1T), which was a 17-alpha alkylated or methylated hormone. In simple terms, 17-Alpha Alkylation/Methylation meant that M1T was highly resistant to breakdown by the liver, making it the most powerful product on the market, causing rapid strength and muscle gains even for long-time steroid users, as well as causing a host of disastrous side effects such as high blood pressure, and dangerous elevation of liver enzymes.


The End of the Beginning


Many in the supplement industry, Arnold among them, argued that the proliferation of powerful products such as M1T would eventually result in negative publicity to attach itself to the supplement industry as a whole and considered it madness that such products had been introduced on to the supplement market. These doomsayers were proven right and eventually the US congress passed into law the Anabolic Steroid Control Act of 2004 which effectively classed all the prohormones then on the market as illegal drugs on a par with anabolic steroids. By early 2005 they had been removed from the market in the United States.


Prohormone Characteristics


A rundown of the actions of individual prohormone products follows so this section shall only cover actions attributable to all classes of prohormone products. This in itself could be an article in its own right so here is the shortened version.

Prohormones exert their effects through several different pathways, but the ones that are most important to people considering using them are their actions via their effects on the body's androgenic, estrogenic and progestogenic receptors. It is through these receptors that prohormone effects are largely mediated, with other pathways of secondary importance.

Prohormones, just like anabolic steroids, are androgen agonists meaning they work via their effect on the androgen receptor. A strong androgen receptor agonist will mean effects related to the male hormone testosterone will be particularly prominent - these include increased aggression, sex drive, alpha male type characteristics in general, as well as heightened risk of side effects related to high androgen levels such as an increased susceptibility to hair loss and acne, although these side effects are very much individual in nature and will depend on the person taking them. They tend to only be an issue for those already susceptible to these conditions.

Linked to these androgenic effects is the propensity for prohormones to induce sizeable increases in muscle strength, large muscle gains, and a hardening effect on the muscles, such that muscles feel denser and more solid. Prohormones that do not convert to estrogen such as Epistane or RPN's Havoc tend to exhibit these types of muscle gains with no water retention.

Away from their effects on androgren receptors, prohormones can also cause effects via estrogen and progesterone receptors. These effects tend to be quite similar in nature - prohormones that convert to estrogen and progesterone have the baility to cause large increases in mass and strength although much of the mass is of a poor quality visually and such gains often disappear rapidly being associated with water retention more than anything else. Estrogenic side effects are feared by most bodybuilders and include increased water weight, increased susceptibility to fat gain in the presence of high estrogen and worst of all, from a cosmetic standpoint at least, the dreaded gynecomastia.

It should be stated that while there are some products which are almost exclusively androgenic in nature with little to no risk of estrogenic/progestogenic side effects (such as Epistane or Havoc), the reverse is not true, in that compounds with high affinity for estrogen and progesterone receptors will still have an impact on the androgen receptor. You will often hear of prohormones being called androgenic or estrogenic or even both, but it should be stated this is often based on their primary method of action and that all will have an androgenic effect at some level, as they all primarily work via their effect on the androgen receptor.

Separate from their effects via androgen, estrogen, and progesterone receptors, prohormones will also differ in their impact on other body systems. Typically, strong androgens are useful for promoting strength gains via the central nervous system (CNS) stimulation, independent of their anabolic or muscle building effects. A strong androgen would often be something similar in nature to Dihydrotestosterone. Furthermore, prohormones will promote enhanced red blood cell production which is why users of prohormones usually experience great pumps and vascularity. Generally speaking, liver toxicity is a concern only for methylated, oral compounds, which is most prohormones nowadays but even then, as the list below shows, they can differ by a wide degree in magnitude of effect.

i may sound like i know a thing or two but im probably talking out of my ass


#3 maximus

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Posted 08 August 2009 - 03:57 PM

Awesome post man!

Sticky this!
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#4 em-dubya

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Posted 08 August 2009 - 06:28 PM

good info...nobody will read it before they start a thread though:)
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#5 Holden Caulfield

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Posted 08 August 2009 - 07:37 PM

thats why all my posts from now on are going to look like this...

http://www.prohormon...scriptions.html


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#6 subseagm

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Posted 08 August 2009 - 07:51 PM

Holden-

Great freaking post!!!! Stuff like this can help tons of people and clear up a lot of confusion!!

#7 Happy234

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Posted 09 August 2009 - 02:16 AM

nice post Holden

#8 Adrenolin

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Posted 09 August 2009 - 02:44 AM

:isee:

Isn't this from Kmul's Link???:fawkyeah:

Prohormones - A Comprehensive Guide Prohormones Article - Updated


Edited by Adrenolin, 09 August 2009 - 02:46 AM.


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#9 ReggieJohal

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Posted 09 August 2009 - 06:36 AM

Hello Holden

I came across the use of my article on your forum and am pleased to join the forum and contribute to any questions your readership have. However, can you please reference at the top of the sticky a link to where it was sourced from as this (feel free to copy and paste the article below). I will also be updating this on a regular basis. If you see any compounds missing please let me know.

Also, if you have any ideas for other articles you think your readership would like to see, or other partnering opportunites where we can jointly assist each other please let me know by email via my site Predator Nutrition or via PM. Ideas would be a joint web seminar, a weekly Q and A etc?

Thank You

Reggie Johal
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#10 KmuL

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Posted 09 August 2009 - 07:05 AM

Hello Holden

I came across the use of my article on your forum and am pleased to join the forum and contribute to any questions your readership have. However, can you please reference at the top of the sticky a link to where it was sourced from as this (feel free to copy and paste the article below). I will also be updating this on a regular basis. If you see any compounds missing please let me know.

Also, if you have any ideas for other articles you think your readership would like to see, or other partnering opportunites where we can jointly assist each other please let me know by email via my site Predator Nutrition or via PM. Ideas would be a joint web seminar, a weekly Q and A etc?

Thank You

Reggie Johal

just added the link, thank you for joining!
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#11 Holden Caulfield

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Posted 09 August 2009 - 01:01 PM

:isee:

Isn't this from Kmul's Link???:fawkyeah:


yep, i read it and though it would make a good sticky in the research section. he gets the credit for finding it, i just reposted it and added color coding.

Hello Holden

I came across the use of my article on your forum and am pleased to join the forum and contribute to any questions your readership have. However, can you please reference at the top of the sticky a link to where it was sourced from as this (feel free to copy and paste the article below). I will also be updating this on a regular basis. If you see any compounds missing please let me know.

Also, if you have any ideas for other articles you think your readership would like to see, or other partnering opportunites where we can jointly assist each other please let me know by email via my site Predator Nutrition or via PM. Ideas would be a joint web seminar, a weekly Q and A etc?

Thank You

Reggie Johal


awsome, glad to see you posting here. if you've got any updates feel free to post them up in this thread. i thought it was a great overview of all the current prohormones but my only question is why you dont mention the use of SERMs for PCT?

Edited by Holden Caulfield, 09 August 2009 - 01:03 PM.

i may sound like i know a thing or two but im probably talking out of my ass


#12 ReggieJohal

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Posted 10 August 2009 - 04:18 AM

Hi Holden

Thanks and I look forward to contributing on the forum.

With regards to PCT I personally cannot really advise too much on specific SERM's given their scheduled nature. There is a PCT article related to supplements at our site but I am unable to link it. There is some degree of marketing involved admittedly but I personally feel too many people look at inhibiting estrogen as the sole aim of PCT when it is just one of several factors that should be considered, and that does not even cover strategies for optimising training and diet.

Reggie

#13 Roun3er

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Posted 10 August 2009 - 12:02 PM

Good info here! Repped brotha


Noticed that you refered to Dymethazine as a "non-methylated" compound in the Side Effects area of Bold 200 profile.
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#14 Holden Caulfield

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Posted 10 August 2009 - 02:09 PM

Good info here! Repped brotha


Noticed that you refered to Dymethazine as a "non-methylated" compound in the Side Effects area of Bold 200 profile.
:ipitythefool:



not my info, just my copy/paste. but good catch on the dymeth, hopefully that gets edited.

i may sound like i know a thing or two but im probably talking out of my ass


#15 Grambo

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Posted 10 August 2009 - 02:52 PM

Good info here! Repped brotha


Noticed that you refered to Dymethazine as a "non-methylated" compound in the Side Effects area of Bold 200 profile.
:ipitythefool:


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#16 Grambo

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Posted 10 August 2009 - 03:42 PM

With Havoc and Epistane they are chemically very slightly different 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol 2 (Havoc), and 2, 3a-epithio-17a-methyletioallo cholan-17b-ol (Epistane)

They are not different at all..... The are the EXACT compound and they just wrote the names differently. No offense but you may need to go back and rewrite some of this stuff. Decent but already found a few mistakes.
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#17 Grambo

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Posted 10 August 2009 - 03:46 PM

"Effects - Bold 200 has the advantage of being non-methylated making it a first choice along with Furazadrol, or Finavol for newcomers to the prohormone field"

Finavol or Tren products are actually not good for newcomers.
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#18 Grambo

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Posted 10 August 2009 - 03:49 PM

"Sold by a number of different brands, including Competitive Edge Labs (X-Tren), and Chaparral Labs (Trenavol) Finavol is APS Nutrition’s version of this compound. This product has Nandrolone as a target hormone and is non-methylated, making it safer on the liver and an excellent choice as part of a prohormone stack."

The 3,4-Estra tren compounds are NOT prohormones to Nandrolone, they are a PH to Dienelone which is similar to nandrolone but has some different properties.

.....Not sure if this should be stickied. Not that too many read them anyway haha

Edited by Grambo, 10 August 2009 - 03:51 PM.

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#19 Holden Caulfield

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Posted 10 August 2009 - 03:50 PM

"Effects - Bold 200 has the advantage of being non-methylated making it a first choice along with Furazadrol, or Finavol for newcomers to the prohormone field"

Finavol or Tren products are actually not good for newcomers.


"Sold by a number of different brands, including Competitive Edge Labs (X-Tren), and Chaparral Labs (Trenavol) Finavol is APS Nutrition’s version of this compound. This product has Nandrolone as a target hormone and is non-methylated, making it safer on the liver and an excellent choice as part of a prohormone stack."

The 3,4-Estra tren compounds are NOT prohormones to Nandrolone, they are a PH to Dienelone which is similar to nandrolone but has some different properties.


i missed both these :facepalm:

should have read this a little harder before trying to get it stickied.
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#20 Grambo

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Posted 10 August 2009 - 03:55 PM

i missed both these :facepalm:

should have read this a little harder before trying to get it stickied.


I actually haven't read it all yet..... ha That was from a browse. We do need an updated version of the new stuff though and I guess this is a start. Just seems like most of this was not done with quite enough research.

I amnot attacking the author other than correcting mistakes in his write up.

Author: Have you used PH/DS/AAS? and if so which ones?
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#21 Dmachine

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Posted 10 August 2009 - 07:49 PM

nice write up

#22 Grambo

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Posted 10 August 2009 - 08:56 PM

I have several notepads worth of errors, things left out and bad info. As well as notes on this piece...... Anyone want me to type it up I will. If not I won't waste my time lol
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#23 Right Hook

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Posted 10 August 2009 - 09:00 PM

Grambo wins.

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#24 Holden Caulfield

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Posted 11 August 2009 - 02:34 AM

I have several notepads worth of errors, things left out and bad info. As well as notes on this piece...... Anyone want me to type it up I will. If not I won't waste my time lol


no i actually did the same thing earlier. i like the write up because its more descriptive than others and it includes the newer compounds that are out right now but there are a few things im taking issue with (probably the same stuff as you). maybe its time for PHF to make our own.

i may sound like i know a thing or two but im probably talking out of my ass


#25 Grambo

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Posted 11 August 2009 - 02:51 AM

Ya there's A LOT lol....

I wish more people read these but maybe if I get a wild hair I could take a stab at it......

I vote to unsticky this personally.




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