It seems that there is a lot of interest in andrenosterone, so I decided to compile most everything I know into an all-in-one... Enjoy!
What is Andrenosterone?
Andrenosterone is a weak androgen that is naturally released from the adrenal cortex (adrenal androgen) along with other glucorticosteroids in response to stress stimuli.
The premise behind andrenosterone is that supplemention of this compound will give the user direct modulation of their cortisol, there-by allowing for excess visceral/adipose fat to be eliminated. The method by how this is done is important to understanding the compound's use. Cortisol, our scapegoat for protein breakdown and fat storage(although cortisol can have a postive effect on fat too...) is a glucorticosteroid released from the adrenal gland, and is also locally synthesized in the body by conversion of free cortisone in the blood via the enzyme 11HSD-R1. By inhibiting this conversion, you are "controlling" cortisol and not eliminating it(which is why I made an allusion to cortisol's positive abilities too, otherwise we could simply inhibit cortisol altogether, but this would not be a good idea).
Dynamics of Adrenosterone
Adrenosterone works in two ways. The first way is alluded to in the previous paragraph, by inhibiting cortisol convertion from cortisone via the 11HSD-R1. Basically, Adrenosterone more efficiently "bonds" to the 11HSD-R1 than cortisone, there-by occupying the receptor and disallowing the synthesization of cortisol. The second way Adrenosterone "works" is also through enzymatic reaction. It turns out, adrenosterone is a prohormone to 11-ketosterone. 11-ketosterone is a non-aromatizable form of testosterone.
1)Obviously, adrenosterone is bio-available. Current brands include:
Ergopharms 11oxo 60caps 75mg/serving
Black China Labs Straight 11 Test 60 caps 50mg/cap
Fast Action Pharma 11 Test 60 caps 100mg/cap
2) The other legitimate delivery system for adrenosterone is through topical application, a.k.a. Transdermal delivery. Right now, there are no companies selling a topical app for adrenosterone. Apparently this isnt DHSEA compliant...
***Dosing guidlines per delivery system***
1)Oral delivery will be composed of cycles lasting 3-9(12 for experienced users) weeks. A low-end oral dose would be 200-300mg QD for 9 weeks. A moderate+ dose is 600-700mg. Obviously, you can create your own dosing regimen, but it would not be uncommon to begin with the 300mg dose and after a few weeks bump it up to the 600mg(or higher) dose and run it at that for the remainder of the cycle. Adrenosterone does become rather suppressive, and more androgenic at the moderate+ dosages. PCT should be included for longer cycles, and shorter cycles where moderate+ dosages are used, or cycles where adrenosterone is "stacked" with other anabolics.
1.5)Bridging Adrenosterone: figured I'd add this here because this is beginning to be a favorite... An "11oxo bridge" is becoming pretty common and it is usually a two-three week addition of adrenosterone to a ph/ds/aas cycle, before PCT is began. Remember, adrenosterone converts to a derivate of testosterone, so this is not a PCT product. Dosing in a bridge should be higher than the moderate dose, 600mg or higher. This is so that you take advantage of adrenosterone's cortisol controlling ability and it's conversion to testosterone derivates. I will address this again, but the user should look to continue to make solid muscular gains on an adrenosterone bridge.
2)Transdermal delivery should be within the 100-300mg QD range, with 300mg being a moderately-high daily dose, assuming the purity of the powdered adrenosterone is very high. More on transdermal application later...
***Parmacodynamics of Adrenosterone***
1)After ingestion, adrenosterone becomes active in approximately an hour, wherein it stays active for 4-5 hours.
2)After being applied topically, adrenosterone will become active more quickly than through oral administration, approximately 30-45 minutes. Peak serum levels will still be around 4-5 hours with this method.
"Spot" fat loss via trandermal application.
This has long been debated as to whether or not it works, but currently, we believe that "spot" fat loss cannot be achieved through excersize, but may be acheivable through transdermal adrenosterone application. The theory is that the adrenosterone will specifically inhibit the conversion of cortisone at the site of local adminstration, as well as throughout the body, but more completely at the site. Empiricle evidence suggests that this is possible with adrenosterone.
How do I make my transdermal adrenosterone since no one is selling it???
There are two ways to do this, both involve removing the contents of the cap. One method involves seperating the fillers, which I'm not going to describe because I really dont want to be responsible for you blowing your house up:D The other method is simply dumping your caps into transdermal gel, which you can purchase on the internet. Depending on the gel, there may be more steps required, but the instructions should be included with whichever gel you purchase.
PCT with adrenosterone
This is necessary with higher/prolonged doses. I will say that an OTC PCT may be used with adrenosterone, but a SERM may be required if you are running doses high enough to mimic exogenous testosterone supplementation.
Cutting with Adrenosterone
The "cut" application seems to be where adrenosterone use is favored the most. So here are some of the expectancies...
You will build muscle on adrenosterone, even in a cut(this is diet prohibitive of course). By this statement, I am referring to adrenosterone's ability to inhibit cortisol(which will cause protein breakdown) and to mimic testosterone.
You can "cut" with adrenosterone, transdermally/orally in low doses, and not need a PCT. Remember, adrenosterone is an endogenous hormone, and I have yet to see any data that suggests that exogenous supplementation will "shutdown" your natural production of adrenosterone. Although, supplementation of higher doses will "shutdown" your natural production of testosterone.
If you are stacking adrenosterone for it's cutting effects, the same rules should apply to its physical actions as if it run standalone. So, a furazadrol/11oxo stack would yeild really good results on body composition, hint hint!
Bulking with adrenosterone
Yes, you read it right, you can definately use adrenosterone to bulk, but the cycle layout is going to require high-end doses and PCT.
To get the most out of adrenosterone IMO, the user should look to use adrenosterone for both it's cortisol controlling abilities and its testosterone mimicing abilities. Diet and exercise should follow suit.
I see no problem stacking adrenosterone with any ph/ds, or supplement for that reason, except maybe creatine(for the purpose of cutting obviously). In fact, adrenosterone would make a good addition to any cycle... not trying to pimp adrenosterone, simply answering the seemingly repetitive question, "can I add 11oxo to my cycle to help me loose fat, even though that's not the main goal of my cycle." In this instance, the low end dose may be all that is necessary.
I will add to this as/if necessary... feel free to make amendments! And also, if there are still any unanswered questions, make them, so I can amend accordingly...
Edited by sammoken, 16 February 2009 - 12:46 PM.