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#326 roydaily

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Posted 13 February 2013 - 08:13 AM

Thank you sir.

#327 Guest_Nor-Natural_*

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Posted 15 February 2013 - 12:51 PM

Franck Ramus1,2, Elizabeth Pidgeon1, Uta Frith1
Article first published online: 23 MAY 2003

DOI: 10.1111/1469-7610.00157

Journal of Child Psychology and Psychiatry
Volume 44, Issue 5, pages 712-722, July 2003


If possible

#328 henryv

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Posted 15 February 2013 - 02:16 PM

Franck Ramus1,2, Elizabeth Pidgeon1, Uta Frith1
Article first published online: 23 MAY 2003

DOI: 10.1111/1469-7610.00157

Journal of Child Psychology and Psychiatry
Volume 44, Issue 5, pages 712-722, July 2003


If possible


Emailed.


#329 Guest_Nor-Natural_*

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Posted 15 February 2013 - 05:18 PM

Emailed.


Thanks a lot

#330 Young JD

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Posted 03 March 2013 - 04:46 AM

Psychopharmacology (Berl). 1982;78(1):38-43.
The effect of IV L-tryptophan on prolactin, growth hormone, and mood in healthy subjects.
Charney DS, Heninger GR, Reinhard JF Jr, Sternberg DE, Hafstead KM.
Abstract
In order to assess the effects of increased CNS serotonergic function in humans on prolactin (PRL), growth hormone (GH), and mood, IV L-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more 'high', 'mellow', and 'drowsy' following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and GH secretion, as well as in mood regulation. The IV TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.
PMID: 6815695 [PubMed - indexed for MEDLINE]
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Can you get this one thanx

#331 Young JD

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Posted 04 March 2013 - 03:22 AM

Am J Obstet Gynecol. 1986 Feb;154(2):424-7.
Influence of sequential doses of 5-hydroxytryptophan on prolactin release.
Sueldo CE, Duda M, Kletzky OA.
Abstract
It is known that the administration of serotonin or its precursors induces the release of prolactin. This study was performed (1) to determine the minimal dose of 5-hydroxytryptophan that would produce a consistent and significant prolactin increase and (2) to establish the frequency of 5-hydroxytryptophan administration necessary to induce a persistent prolactin increase. Nine normal male subjects participated in 27 independent studies following pretreatment with 100 mg of carbidopa given every 8 hours for 2 days. Doses of 0.2, 0.4, and 0.8 mg/kg/hr of 5-hydroxytryptophan were initially infused for 30 minutes, and serum prolactin was measured every 15 minutes for 2 1/2 hours. The urinary 5-hydroxyindoleacetic acid/creatinine ratio was determined in aliquots collected during 3 hours before, during, and after the intravenous infusion. 5-Hydroxytryptophan at a dosage of 0.4 mg/kg/hr was the minimal amount to elicit a consistent and significant prolactin increase (p less than 0.01). A positive correlation (r = 0.907, p less than 0.002) was also demonstrated between the maximal prolactin response and the 5-hydroxyindoleacetic acid/creatinine ratio. Thus 0.4 mg/kg/hr of 5-hydroxytryptophan was administered sequentially three times at intervals of 2, 4, 6, 8, and 12 hours. With exception of the 12-hour interval a significantly smaller plasma prolactin increase was seen following the third dose of 5-hydroxytryptophan (p less than 0.05). Furthermore, the nadir for this diminished prolactin response occurred at 4 hours (p less than 0.01). This phenomenon may represent a down regulation of the serotonin receptors induced by the repetitive administration of 5-hydroxytryptophan. In conclusion, this study has demonstrated a dose-related prolactin response to increasing doses of 5-hydroxytryptophan. The maximum down regulation of prolactin release occurred when 5-hydroxytryptophan was administered at 4-hour intervals. And this one

#332 Young JD

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Posted 04 March 2013 - 03:36 AM

J Chromatogr A. 2012 Apr 6;1232:158-65. doi: 10.1016/j.chroma.2011.11.037. Epub 2011 Dec 1.
Determination of serotonin and its precursors in chocolate samples by capillary liquid chromatography with mass spectrometry detection.
Guillén-Casla V, Rosales-Conrado N, León-González ME, Pérez-Arribas LV, Polo-Díez LM.
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Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, E-28040 Madrid, Spain. vguillen@quim.ucm.es
Abstract
A method for the analysis of serotonin (5-HT) and its precursors, 5-hydroxytryptophan (5-HTP) and l-tryptophan (TP) in chocolate samples by capillary liquid chromatography-mass spectrometry (cLC-MS) has been developed. Optimum chromatographic conditions were established by using a personalized multifactorial experimental design. Finally the cLC separation was achieved through a mixture of acetonitrile and 5mM ammonium formate at pH 4 (3:97, v/v) as mobile phase in gradient elution, setting the injection volume at 10 μL and using pure water as injection solvent for focusing purposes on the head of the capillary column. For extraction of targets in chocolate samples a new, fast and simple procedure based on the use of acidic extraction medium and sonication was developed. Working in selected ion mode (m/z 177 for 5-HT, m/z 205 for l-tryptophan and m/z 221 for 5-HTP) detection limits were between 0.01 and 0.11 μg g(-1) and linearity was in the concentration range of 0.5-25 μg g(-1). Recoveries higher than 76% with RSDs lower than 8% were obtained from spiked samples for all analytes, showing the effectiveness of the proposed method. Serotonin and its precursors were determined in 5 kinds of commonly consumed chocolates with different cocoa contents (70-100%). The highest serotonin content was found in chocolate with a cocoa content of 85% (2.93 μg g(-1)). Regarding l-tryptophan, the highest content of this amino acid (13.27-13.34 μg g(-1)) was found in chocolate samples with the lowest cocoa content (70-85%). 5-Hydroxytryptophan was not detected in any chocolate samples.
Copyright © 2011 Elsevier B.V. All rights reserved.
PMID: 22186492 [PubMed - indexed for MEDLINE]
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And this one

#333 Young JD

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Posted 04 March 2013 - 06:04 AM

Home |1974 Archive |April 1974 |KATO et al. 38 (4): 695
COMMENT
Effect of 5-Hydroxytryptophan (5-HTP) on Plasma Prolactin Levels in Man
YUZURU KATO, YOSHIKATSU NAKAI, HIROO IMURA, KAZUO CHIHARA and SHQZO OHGO
- Author Affiliations

Third Division, Department of Medicine, Kobe University School of Medicine Kobe, Japan
Second Division, Department of Medicine, Kyoto University School of Medicine Kyoto, Japan
ABSTRACT

Oral administration of 5-hydroxytryptophan (5-HTP, 200 mg), a precursor of serotonin, significantly increased plasma human prolactin (hPr) levels in 18 of 21 normal subjects examined. Concomitant intravenous infusion of cyproheptadine (5 mg), a serotonin antagonist, significantly blunted the plasma hPr response to 5-HTP. These results suggest that the serotonergic mechanism is involved in the regulation of prolactin secretion in man.

Received November 23, 1973.
Copyright © 1974 by The Endocrine Society. And this one

#334 Young JD

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Posted 01 April 2013 - 03:53 AM

The occurrence of estrone and estriol intrichostrongylus colubriformis (nematoda)
Hui-Minn Lee, Edward J. Parish, Leon W. Bone
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Abstract
Mammalian sex steroids and cholesterol wre isolated from the lipid extract of the zooparasitic nematodeTrichostrongylus colubriformis. In addition to the previously identified sex steroids progesterone and testosterone, estrone and estriol were detected and isolated from the mixture. The steroids were analyzed by thin-layer gas-liquid and high-performance liquid chromatography, and their structures confirmed by proton nuclear magnetic resonance and mass spectroscopy. Can any one get this pls

#335 henryv

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Posted 09 May 2013 - 06:42 AM

http://www.discussbo.../pheraplex1.pdf
Interesting


#336 Young JD

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Posted 20 May 2013 - 03:13 AM

Journal of Steroid Biochemistry
Volume 5, Issue 4, June 1974, Pages 317


4A 1. Steroid catabolism: Androgens—I
89. Androsta-1,4-diene-3,17,19-trione: Its provisional identification as a new placental metabolite of androstenedione
K.H. Loke
http://dx.doi.org/10...4731(74)90234-9, How to Cite or Link Using DOI
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There are no figures or tables for this document.

Copyright © 1974 Published by Elsevier Ltd.
Any one able to get this plz

#337 brymaster

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Posted 24 May 2013 - 09:57 PM

Any one able to get this plz


You take a peculiar interest in certain hormone research, but to each their own. :)

Attached File  Androstadienetrione.pdf   121.57KB   18 downloads

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#338 Young JD

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Posted 26 May 2013 - 07:33 AM

Thanks for the study bro
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#339 Young JD

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Posted 10 June 2013 - 06:48 AM

Biol Pharm Bull. 1995 Apr;18(4):555-8.
Biochemical studies of estr-4-ene-3,6,17-trione and 5 alpha-androstan-17-ones with or without a carbonyl function at C-3 and/or C-6 as aromatase inhibitors.
Numazawa M, Mutsumi A, Tachibana M, Nagaoka M.
Source
Tohoku College of Pharmacy, Sendai, Japan.
Abstract
19-Nor (2) and 5 alpha-reduced (3) derivatives of androst-4-ene-3,6,17-trione (1) as well as 5 alpha-androstan-17-ones 4-6 were tested for their abilities to inhibit aromatase in human placental microsomes. All the steroids except 5 alpha-6-one 4 were fair to good competitive inhibitors of the enzyme, with apparent Ki's ranging from 50 to 820 nM in which 5 alpha-3-one 5 was the most potent among them. The inhibitory activities of the 19-nor and 5 alpha-reduced derivatives (2 and 3) were less potent than that of the parent compound 1. Inhibitor 2 caused a time-dependent, pseudo-first-order inactivation of aromatase activity with a rate constant for inactivation of 0.148 min-1 in the presence of NADPH in air. The substrate androstenedione prevented the inactivation and L-cysteine did not protect aromatase from the inactivation.
PMID: 7655426 [PubMed - indexed for MEDLINE]
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Any body able to get this

#340 henryv

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Posted 11 June 2013 - 06:55 AM

Androsta-3,5-diene-7,17-dione: isolation from urine and formation from 7-keto-dehydro-epiandrosterone sulphate under various conditions of hydrolysis. Endocrinol Exp. 1971 Dec;5(4):205-10.


#341 harbonah

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Posted 11 June 2013 - 02:06 PM

Any chance anyone has this paper? "Greer,M. N Engl J Med 244:385, 1951"

#342 henryv

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Posted 11 June 2013 - 02:52 PM

Any chance anyone has this paper? "Greer,M. N Engl J Med 244:385, 1951"


Link to abstract: The Effect on Endogenous Thyroid Activity of Feeding Desiccated Thyroid to Normal Human Subjects


#343 brymaster

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Posted 11 June 2013 - 05:48 PM

Biol Pharm Bull. 1995 Apr;18(4):555-8.
Biochemical studies of estr-4-ene-3,6,17-trione and 5 alpha-androstan-17-ones with or without a carbonyl function at C-3 and/or C-6 as aromatase inhibitors.
Numazawa M, Mutsumi A, Tachibana M, Nagaoka M.
Source
Tohoku College of Pharmacy, Sendai, Japan.
Abstract
19-Nor (2) and 5 alpha-reduced (3) derivatives of androst-4-ene-3,6,17-trione (1) as well as 5 alpha-androstan-17-ones 4-6 were tested for their abilities to inhibit aromatase in human placental microsomes. All the steroids except 5 alpha-6-one 4 were fair to good competitive inhibitors of the enzyme, with apparent Ki's ranging from 50 to 820 nM in which 5 alpha-3-one 5 was the most potent among them. The inhibitory activities of the 19-nor and 5 alpha-reduced derivatives (2 and 3) were less potent than that of the parent compound 1. Inhibitor 2 caused a time-dependent, pseudo-first-order inactivation of aromatase activity with a rate constant for inactivation of 0.148 min-1 in the presence of NADPH in air. The substrate androstenedione prevented the inactivation and L-cysteine did not protect aromatase from the inactivation.
PMID: 7655426 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
Any body able to get this


You can obtain this free of charge JD. ;)

https://www.jstage.j..._4_555/_article

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#344 Young JD

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Posted 11 June 2013 - 10:09 PM

You can obtain this free of charge JD. ;)

https://www.jstage.j..._4_555/_article


Thanks bro

#345 Young JD

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Posted 22 June 2013 - 01:20 AM

Any able to get this Display Settings:AbstractSend to:
Bioresour Technol. 2001 Jun;78(2):209-11.
Biotransformation of cholesterol using Lactobacillus bulgaricus in a glucose-controlled bioreactor.
Kumar R, Dahiya JS, Singh D, Nigam P.
Source
Prairie Biological Research Lab, Inc, Edmonton, Alberta, Canada.
Abstract
A novel single-step microbial transformation process for the production of testosterone from cholestrol by Lactobacillus bulgaricus in an aerated fermenter was investigated. The metabolism of glucose possibly supplying reducing power as NADH was necessary for the reduction of androst-4-en-3,17-dione (AD) to testosterone (TS). The growth period for the accumulation of testosterone in maximal amount and the residual glucose increased in parallel with the amount of glucose supplement in growth cultures. After the glucose in the fermentation culture was completely exhausted, most of the testosterone was oxidized to AD. Addition of a larger amount of glucose could prevent oxidation of testosterone to AD. The biotransformation of cholestrol was significantly increased in the presence of cyclodextrin (CD) in the fermenting medium. The addition of 0.1% CD to the growth medium facilitated the transport of the steroid substrate through the microbial cell wall.
PMID: 11333043 [PubMed - indexed for MEDLINE]
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#346 brymaster

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Posted 01 July 2013 - 10:24 AM

Any able to get this Display Settings:AbstractSend to:
Bioresour Technol. 2001 Jun;78(2):209-11.
Biotransformation of cholesterol using Lactobacillus bulgaricus in a glucose-controlled bioreactor.
Kumar R, Dahiya JS, Singh D, Nigam P.
Source
Prairie Biological Research Lab, Inc, Edmonton, Alberta, Canada.
Abstract
A novel single-step microbial transformation process for the production of testosterone from cholestrol by Lactobacillus bulgaricus in an aerated fermenter was investigated. The metabolism of glucose possibly supplying reducing power as NADH was necessary for the reduction of androst-4-en-3,17-dione (AD) to testosterone (TS). The growth period for the accumulation of testosterone in maximal amount and the residual glucose increased in parallel with the amount of glucose supplement in growth cultures. After the glucose in the fermentation culture was completely exhausted, most of the testosterone was oxidized to AD. Addition of a larger amount of glucose could prevent oxidation of testosterone to AD. The biotransformation of cholestrol was significantly increased in the presence of cyclodextrin (CD) in the fermenting medium. The addition of 0.1% CD to the growth medium facilitated the transport of the steroid substrate through the microbial cell wall.
PMID: 11333043 [PubMed - indexed for MEDLINE]
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Biotransformation of cholesterol using Lactobacillus bulgaricus in a glucose-controlled bioreactor

if i were you, i'd just rent this for < $1 on deepdyve. i have an account there (free of charge) and have found it to come in handy quite often. just a suggestion.

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#347 tvhatic

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Posted 05 July 2013 - 10:44 AM

Gas chromatographic and mass spectrum analysis of the alkaloids of Dendrobium nobile cultivated on eleven trees

Wang, X. K.

Zhong yao tong bao (Beijing, China : 1981)MEDLINE Abstracts - Aug 1, 1985



Anyone have access to Chinese journals?

#348 henryv

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Posted 26 July 2013 - 12:14 PM

Azadian-Boulanger, G, Bucourt, R, Nédélec, L, Nominé, G: Stéroides triéniques androgènes et anabolisants. Eur J Med Chem 1975 10: 353-359


#349 henryv

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Posted 23 August 2013 - 04:16 AM

Evaluation of androgenic activity of nutraceutical... [Anal Chem. 2011] - PubMed - NCBI


#350 tvhatic

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Posted 09 September 2013 - 12:33 PM

Also
ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7


You ever find this one? Also interested.




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