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#51 henryv

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Posted 23 August 2011 - 11:01 AM

Effect of 1-alkyl substitution on the biological a... [Steroids. 1966] - PubMed result

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#52 henryv

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Posted 23 August 2011 - 11:19 AM

same story here, henry, I can get it in print but not online. I'll try to get all three articles (for right hook, brymaster and henryv) tonight or tomorrow


Burn down the library. Then ask for the PDF.

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#53 Right Hook

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Posted 23 August 2011 - 12:57 PM

Rep simon if you havent all.
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#54 henryv

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Posted 23 August 2011 - 01:13 PM

Rep simon if you havent all.


I gave him a kidney. Wasn't that enough?
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#55 henryv

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Posted 23 August 2011 - 01:36 PM

a liver would be nice, because I might need one for my impending 8 week M1T/superdrol/ultradrol cycle


You'll take Stuess' kidney and be grateful.

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#56 Doctor Steuss

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Posted 23 August 2011 - 01:51 PM

Last time I listen to Henryv...

"Get in the bathtub with ice," he says. "It's huge in the UK right now," he says. "New form of plaking," he says.

:isee:
Deferential, glad to be of use,

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Full of high sentence, but a bit obtuse;

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#57 henryv

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Posted 24 August 2011 - 05:37 AM

Effect of 1-alkyl substitution on the biological action in a series of androstanes.pdf


here you go boys and girls. The quality isn't as good as it normally is because I had to scan them myself rather than get them off a database, but they are certainly readable.

Learn something new!

edit: I couldn't use the PHF attachment wizard thing because the files were too large so I had to upload them to a file-sharing site. These are the download links


That's awesome, thanks. I love the ones that look like they were typed on a typewriter.

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#58 brymaster

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Posted 24 August 2011 - 10:53 AM




Biological activity in steroids possessing nitrogen atoms recent advances.pdf


Much appreciated man. Reps on spread.
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#59 henryv

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Posted 25 August 2011 - 05:25 PM

Disposition of 17 beta-trenbolone in humans. [J Chromatogr. 1991] - PubMed - NCBI

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#60 henryv

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Posted 26 August 2011 - 02:37 PM

Pharmacophore modeling strategies for t... [Bioorg Med Chem Lett. 2010] - PubMed - NCBI

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#61 henryv

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Posted 26 August 2011 - 03:40 PM

[ATTACH]4797[/ATTACH]

The volume/issue that you posted contains the correction that was apparently published to the original article. Here's the correction and the originally published article was too big to attach here and I reached my free limit on that file-hosting site I used before, so I just emailed it to you. If anyone else wants it, PM with your email


Thank you. It doesn't always have to be you that does this, stop anytime you like.

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#62 henryv

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Posted 26 August 2011 - 03:56 PM

no worries. I have pretty good access to a lot of articles so I figure I might as well take advantage of it. It's not like there is a limit to how much research my university lets me do or anything. Also, I look up most of these while I'm at work with nothing else to do.


Inb4 DEA raid for looking up too much steroid stuff.

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#63 brymaster

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Posted 05 September 2011 - 12:59 PM

same story here, henry, I can get it in print but not online. I'll try to get all three articles (for right hook, brymaster and henryv) tonight or tomorrow


been trying to rep you for some time now, but gotta spread the love.

brb repping 5 people
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#64 Right Hook

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Posted 18 October 2011 - 07:42 PM

Anyone help a brudda out?

Med Sci Sports Exerc. 2011 Oct 8. [Epub ahead of print]

Intracrine and Myotrophic Roles of 5a Reductase and Androgens: A Review.

Yarrow JF, McCoy SC, Borst SE.


Source

1VA Medical Center, Gainesville FL, United States, 32608; 2Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville FL, United States. 32608 3Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States, 32611.


Abstract

Historically, the circulation was thought to be the primary source of androgens influencing skeletal muscle. However, a growing body of research indicates that skeletal muscle expresses several androgen synthesizing enzymes, including 5α reductase. The intramuscular expression of these enzymes suggests that skeletal muscle is capable of synthesizing bioactive androgens which could induce myotrophic effects via intracrine action.

PURPOSE:

The aim of this brief review is to discuss recent research related to the intracrine and myotrophic roles of androgens, with particular focus on 5a reductase as a myotrophic mediator.

METHODS:

Included in the review are 17 reviews and 58 original studies which were identified by a systematic review from MEDLINE and deemed particularly relevant to our purpose. Results are summarized to provide an overview of 5a reductase as a mediator of the myotrophic effects of androgens. In particular, discussions are included regarding androgen biosynthesis and androgen signaling within skeletal muscle, the effects of exercise on intramuscular androgen biosynthesis, and clinical applications of androgens and of a new class of myotrophic agonists termed selective androgen receptor modulators (SARMs).

RESULTS:

The ability of several peripheral tissues to synthesize bioactive androgens is well documented in the literature. Herein, we summarize newer studies which demonstrate that 1) skeletal muscle has the capability to synthesize both testosterone and dihydrotestosterone (DHT) from dehydroepiandrosterone (DHEA), which is present in abundance within the circulation and 2) that exercise increases the expression of certain androgen biosynthesizing enzymes within muscle.

CONCLUSION:

Intramuscularly synthesized androgens have the potential to influence skeletal muscle via intracrine action; however, their exact role in skeletal muscle development and maintenance requires further elucidation.


PMID: 21988936 [PubMed - as supplied by publisher]


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#65 Doctor Steuss

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Posted 19 October 2011 - 09:37 AM

[ATTACH]5311[/ATTACH]


On spread.
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Deferential, glad to be of use,

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Full of high sentence, but a bit obtuse;

At times, indeed, almost ridiculous---

Almost, at times, the Fool.

--Elliot

#66 Right Hook

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Posted 19 October 2011 - 10:32 PM

[ATTACH]5311[/ATTACH]


Fantastic. Thank you

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#67 Natty Disaster

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Posted 25 October 2011 - 02:28 AM

lol...thread starter as not posted since starting the thread
Physique Enhancing Science - Get Enhanced.

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#68 henryv

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Posted 31 October 2011 - 10:07 PM

[The endocrinologic profile of metabolites of the ... [Pharmazie. 1993] - PubMed - NCBI

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#69 henryv

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Posted 04 November 2011 - 01:22 PM

[ATTACH]5424[/ATTACH]


Anyone speak German? I know the aromatic metabolite we're all interested in is labelled "STS 825".

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#70 mcalex

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Posted 04 November 2011 - 11:12 PM

I do.What do you want to know exactly ?

#71 henryv

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Posted 05 November 2011 - 04:36 AM

I do.What do you want to know exactly ?


If there's any discussion about how much of the aromatic metabolite STS 825 is produced, or any indication of the enzymatic reactions that cause it, I guess.

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#72 Young JD

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Posted 12 November 2011 - 01:49 AM

Abstract - selected Article Figures/Tables References

*

Steroids
Volume 63, Issue 10, October 1998, Pages 542-553
doi:10.1016/S0039-128X(98)00066-X*|*How to Cite or Link Using DOI
Cited By in Scopus (17)
**Permissions & Reprints

Papers

Ergosteroids III. syntheses and biological activity of seco-steroids related to dehydroepiandrosterone
IevaL*Reich∗,*†,*, Henry*Lardy∗,*†,*1, Yong*Wei∗, Padma*Marwah∗, Nancy*Kneer∗, DouglasR*Powell†, HansJ*Reich†


Purchase

∗ Institute for Enzyme Research, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA
† Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA
Received 12 May 1998; Accepted 6 July 1998. Available online 22 December 1998.

Abstract
The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats’ livers. Only one, 3β-acetoxy-17a-oxa-androst-5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β-hydroxy-17a-oxa-androsta-5,15-diene-7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β-Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D-ring seco compounds enhanced the formation of both enzymes. Twelve other D-ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active.

Keywords: ergosteroids; 7-oxo-DHEA; DHEA; seco-steroids; thermogenic enzymes

Article Outline
Introduction
Experimental
Syntheses
Synthesis of 16,17-dione and D-Ring seco androsterones
3β-(trimethylsilyl)acetoxy-17-hydroxyandrosta-5,16-dien-7-one trimethylsilyl ether (2)
3β-acetoxy-16α-phenyl selenoandrost-5-ene-7,17-dione (5)
3β,16-diacetoxy-16-phenylselenoandrost-5-ene-7,17-dione (6)
3β,16-diacetoxyandrosta-5,15-diene-7,17-dione (7)
3β-acetoxyandrost-5-ene-7,16,17-trione (8)
3β-acetoxy-7-oxo-16,17-secoandrost-5-ene-16,17-dioic acid (9)
Dimethyl 3β-acetoxy-7-oxo-16,17-secoandrost-5-ene-16,17-dioate (10)
3β-acetoxy-7-oxo-16,17-secoandrost-5-en-17-oic acid (12a)
3β-acetoxy- 7-oxo-16,17-secoandrost-5-ene-16,17-dioic acid, 16 and 17-methyl half-esters (12b and 12c)
Preparation of D-Ring lactones
3β-propionoxy-17a-oxa-14α-androsta-5,15-diene-7,17-dione (13)
3β-hydroxy-17a-oxa-14α-androsta-5,15-diene-7,17-dione (14)
3β-hydroxy-17a-oxa-14β-androsta-5,15-diene-7,17-dione (15)
3β-acetoxy-17a-oxa-14β-androsta-5,15-diene-7,17-dione (16)
3β-acetoxy-17a-oxa-androst-5-ene-7,17-dione (17)
3β-acetoxy-17-oxa-androst-5-en-17a-one (18) and 3β-acetoxy-17a-homo-17-oxa-androst-5-en-16-one (19)
3β-acetoxy-17-oxa-androst-5-ene-7,17a-dione (20) and 3β-acetoxy-17a-homo-17-oxa-androst-5-ene-7,16-dione (21)
Degradation of the chenodeoxycholic acid side chain
Methyl 3α,7α-dihydroxy-5β-cholan-24-oate (23)
Methyl 3α,7α-dihydroxy-5β-chol-22-en-24-oate (25)
Methyl 3α,7α-bis(tert-butyldimethylsilyloxy)-5β-chol-20-en-24-oate (26)
3α,7α-bis(tert-butyldimethylsilyloxy)-5β-pregnan-20-one (27)
3α,7α-bis(tert-butyldimethylsilyloxy)-17β-acetoxy-5β-androstane (28), 4-oxa-4a-homo-7α-tert-butyldimethylsilyloxy-17β-acetoxy-5β-androstan-3-one (29) and 3α-tert-butyldimethylsilyloxy-7a-oxa-17β-acetoxy-5β-androstan-7-one (30)
4-oxa-4a-homo-7α-hydroxy-17β-acetoxy-5β-androstan-3-one (31)
3α-hydroxy-7a-oxa-17β-acetoxy-5β-androstan-7-one (32)
Formation of B-Ring lactones by peroxidation of 7-keto steroids
3β,17β-diacetoxy-7a-oxa-5α-androstan-7-one (34)
3β,17β-diacetoxy-5α,6-epoxy-androstan-7-one (36)
3β,17β-diacetoxy-5α,6-epoxy-7a-oxa-androstan-7-one (37) and 3β,17β-diacetoxy-5α,6-epoxy-7-oxa-androstan-7a-one (38)
3β,17β-diacetoxy-5α-formyl-6-oxa-androstan-7-one (39)
Biological activity: results and discussion
Acknowledgements
References

Address reprint requests to Ieva L Reich, Department of Chemistry, 1101 University Avenue, Madison, WI 53706 or Henry Lardy

1Institute for Enzyme Research, 1710 University Avenue, Madison, WI 3705, USA.




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Copyright © 1998 Elsevier Science Inc. All rights reserved.
Steroids
Volume 63, Issue 10, October 1998, Pages 542-553
Any one able to get full text of these

#73 Young JD

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Posted 15 November 2011 - 02:46 AM

[ATTACH]5506[/ATTACH]


Thanks for that

#74 Young JD

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Posted 19 November 2011 - 05:38 AM

Synthesis of (15E)-17β-hydroxy-5α-androstane-3,15-dione 15-[O-(Carboxymethyl)]oxime, New Hapten for Dihydrotestosterone (17β-hydroxy-5α-androstan-3-one)
Ivan Černý, Tereza Slavíková and Vladimír Pouzar
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
Abstract
Addition of 4-methoxybenzyl alcohol to 3β-hydroxy-5α-androst-15-en-17-one gave the mixture of isomeric 15-(4-methoxyphenyl)methoxy derivatives from which, after acetylation and chromatography, the major 15β isomer was separated. Borohydride reduction gave 17β-hydroxy derivative which was protected as methoxymethyl ether. Oxidative cleavage of protecting group at position 15 and the subsequent Jones oxidation afforded corresponding 15-ketone. Its oximation with O-(carboxymethyl)hydroxylamine, deacetylation and methylation with diazomethane gave protected O-(carboxymethyl)oxime derivative with free hydroxy group at position 3. Its oxidation afforded dihydrotestosterone derivative and successive deprotection of position 17 and of carboxy group led to final (15E)-17β-hydroxy-5α-androstane-3,15-dione 15-[O-(carboxymethyl)]oxime. The title compound was designed as dihydrotestosterone hapten for heterologous radioimmunoassays.

Keywords: Steroids; DHT; CMO; Protecting groups; MPM; Hapten.
Any one able to get full text for this looks interesting

#75 Young JD

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Posted 26 November 2011 - 05:43 AM

[ATTACH]5565[/ATTACH]


Thanks for this




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