Is there any evidence to suggest that ursolic has any effect on the nerves that feed muscles. I am very interested in this product since I have a type of neuromuscular atrophy that has been slowly wasting away my leg muscles over the last 25 years. Ideally I would like a product that increases the strength of the signal from the nerves to the leg muscles but any product that is anti-catabolic is desirable.
The study done on UA was as a way to reduce muscle wasting. from just such an ailment. I am not sure if will aid in regenerating nerves. I did find this abstract that suggests it might
fect of ursolic acid on nerve regeneration by activating AKT/mTOR signaling pathway
Effect of ursolic acid on nerve regeneration by activating AKT/mTOR signaling pathway
Author Block: *J.-W. KIM1, M. KIM1, H. AN1, J. HONG1, J. JUN1, A. JI2, J. HYUN1,2,3;
1Dept. of Nanobiomedical Sci. and WCU Res. Ctr., 2Inst. of Tissue Regeneration Engin., 3Dept. of Rehabil. Medicine, Col. of Med., Dankook Univ., Cheonan-Si, Korea, Republic of
Disclosure Block: J. Kim: Research Grant; NRF 2012011783. M. Kim: None. H. An: None. J. Hong: None. J. Jun: None. A. Ji: None. J. Hyun: None.
Ursolic acid (UA), a pentacyclic triterpene acid, has many biological functions, including anti-cancer, anti-inflammatory effects, and neuroprotective effect. However it is not known whether UA can promote axonal outgrowth and regulate Akt and mTOR signaling pathways. In this study, we investigated the effect of UA on neurite outgrowth of dorsal root ganglion (DRG) neurons from young adult Sprague-Dawley rats. DRG neurons were treated with UA in variable concentrations for 24 hrs. We found that UA promote to increase the maximal neurite length of DRG in the some range of concentrations. As a positive control, we used two PTEN inhibitors, BpV (HOpic) and BpV (phen). Compare with PTEN inhibitors, UA had a similar effect on axonal outgrowth. Furthermore, we revealed that UA increased level of phosphorylated Akt and mTOR in DRG with a dose-dependent manner measured by Western blot analysis. However the level of phosphorylated Akt and mTOR and the maximal neurite length of DRG were decreased at high concentration (10 μM) of UA. We conclude that UA can promote neurite outgrowth of DRG by upregulation of Akt and mTOR signaling pathway.