Jump to content



Official Store


- - - - -

Hyaluronic Acid

available beta cycles growth heat joint molecular products proteins weight

  • Please log in to reply
5 replies to this topic

#1 Mmats

Mmats

    Junior Member

  • Members
  • Pip
  • 5 posts

Posted 22 August 2013 - 05:25 PM

Is this saying that 5g of hyaluronic acid are synthesized daily? Seems ridiculous considering the small amount that companies are putting in joint formulas.

Abstract
A new pathway of intermediary metabolism is described involving the catabolism of hyaluronan. The cell surface hyaluronan receptor, CD44, two hyaluronidases, Hyal-1 and Hyal-2, and two lysosomal enzymes, beta-glucuronidase and beta-N-acetylglucosaminidase, are involved. This metabolic cascade begins in lipid raft invaginations at the cell membrane surface. Degradation of the high-molecular-weight extracellular hyaluronan occurs in a series of discreet steps generating hyaluronan chains of decreasing sizes. The biological functions of the oligomers at each quantum step differ widely, from the space-filling, hydrating, anti-angiogenic, immunosuppressive 10(4)-kDa extracellular polymer, to 20-kDa intermediate polymers that are highly angiogenic, immuno-stimulatory, and inflammatory. This is followed by degradation to small oligomers that can induce heat shock proteins and that are anti-apoptotic. The single sugar products, glucuronic acid and a glucosamine derivative are released from lysosomes to the cytoplasm, where they become available for other metabolic cycles. There are 15 g of hyaluronan in the 70-kg individual, of which 5 g are cycled daily through this pathway. Some of the steps in this catabolic cascade can be commandeered by cancer cells in the process of growth, invasion, and metastatic spread.


ht tp:/ /ww w.ncbi.nlm.nih. gov/pubmed/15503855

#2 00S4boy

00S4boy

    Celtic Labs Rep

  • Reps
  • 1,190 posts

Posted 22 August 2013 - 05:29 PM

Is this saying that 5g of hyaluronic acid are synthesized daily? Seems ridiculous considering the small amount that companies are putting in joint formulas.



ht tp:/ /ww w.ncbi.nlm.nih. gov/pubmed/15503855


Actually that article is saying that the average 70 kilogram person will have an average of 15g of hyaluronic acid and the pathway of metabolism they are describing in the human body will metabolize 5g of the 15 an average person has not including exogenous supplementation.

Celtic Labs Rep

WARNING

OUR PRODUCTS MAY INCREASE MUSCLE SIZE


#3 Mmats

Mmats

    Junior Member

  • Members
  • Pip
  • 5 posts

Posted 22 August 2013 - 06:06 PM

Actually that article is saying that the average 70 kilogram person will have an average of 15g of hyaluronic acid and the pathway of metabolism they are describing in the human body will metabolize 5g of the 15 an average person has not including exogenous supplementation.


So 5 grams are synthesized by the body every day? Thats alot... No point in supplementing 100mg of the stuff.

#4 00S4boy

00S4boy

    Celtic Labs Rep

  • Reps
  • 1,190 posts

Posted 22 August 2013 - 06:55 PM

So 5 grams are synthesized by the body every day? Thats alot... No point in supplementing 100mg of the stuff.


That article has no mention of synthesis only that the average 70kg person has an average of 15g in their body and the pathway of metabolism will destroy 5g's a day not mentioning other pathways of metabolism.

Celtic Labs Rep

WARNING

OUR PRODUCTS MAY INCREASE MUSCLE SIZE


#5 Mmats

Mmats

    Junior Member

  • Members
  • Pip
  • 5 posts

Posted 23 August 2013 - 04:39 PM

That article has no mention of synthesis only that the average 70kg person has an average of 15g in their body and the pathway of metabolism will destroy 5g's a day not mentioning other pathways of metabolism.


If the pathway is destroying 5g's per day, doesnt it go without saying that the body is reproducing at least 5g's per day? Otherwise there is no way you could expect someone to average a total of 15g's...

#6 mr.cooper69

mr.cooper69

    Senior Member

  • Members
  • 345 posts

Posted 01 September 2013 - 08:07 PM

Yes, it's saying you make 5g hyaluronic acid daily. And yes, oral hyaluronic acid is a waste





Also tagged with one or more of these keywords: available, beta, cycles, growth, heat, joint, molecular, products, proteins, weight

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users