Jump to content





Photo
- - - - -

Effects Of Synthetic Androgens On Liver Function Using The Rabbit As A Model


  • Please log in to reply
3 replies to this topic

#1 superman21

superman21

    Senior Member

  • Members
  • 159 posts

Posted 20 October 2014 - 09:35 PM

Abstract

The objective of this study was to determine whether the rabbit was a suitable model to test new synthetic androgens for potential liver toxicity within a short dosing interval. Adult male rabbits were dosed orally daily on days 0-13 with 17α-methyltestosterone (MT) as a positive control and testosterone (T) as a negative control to validate this model. Synthetic androgens tested were: 7α-methyl-19-nortestosterone (MENT), dimethandrolone-undecanoate (DMAU), and 11β-methyl-19-nortestosterone-17β-dodecylcarbonate (11β-MNTDC). Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), and sorbitol dehydrogenase (SDH), as well as clearance of intravenous injected bromsulfonphthalein (BSP) from serum on days 0, 7, and 14, were determined. As expected, T (10 mg/kg/d) did not adversely affect BSP retention or serum liver enzymes. MT (10 mg/kg/d) increased BSP retention, and AST, ALT, GGT, and SDH levels, indicating that this model could detect androgens known to be hepatotoxic. DMAU and MENT (10 mg/kg/d) increased BSP retention and all 4 serum liver enzymes as well, but the effects were less than those observed with MT at the same dose. All parameters returned to baseline 2 weeks after cessation of dosing. 11β-MNTDC at 10 mg/kg/d did not have an effect on BSP retention or liver enzymes, but a slight increase in serum GGT levels was observed in rabbits treated with 25 mg/kg/d. For the androgens that exhibited liver toxicity at 10 mg/kg/d (MT, DMAU, and MENT), a no-observed-effect level of 1 mg/kg/d was established. Overall ranking of the synthetic androgens from most to least hepatotoxic on the basis of percent BSP retention was: MT & DMAU > MENT > 11β-MNTDC. Hence, the rabbit appears to be a promising model for detection of potential liver toxicity by synthetic androgens using BSP clearance and serum liver enzyme levels as early indicators of injury.

 

http://www.ncbi.nlm....pubmed/20378929

 

for the unawares MENT is more toxic than Test....


  • Majora23 likes this

#2 Majora23

Majora23

    Saiyan

  • Members
  • 846 posts

Posted 20 October 2014 - 09:42 PM

Cool man, good info. Always kinda figured it would be more toxic than test.

#3 scuncknuts

scuncknuts

    Member

  • Members
  • 452 posts

Posted 22 November 2014 - 04:24 PM

omg 10/mg/kg would be like me taking 1000 of MENT I wonder what those rabbits looked like they probably had a raging hard on



#4 henryv

henryv

    Mr. Picky Pants

  • Super Moderators
  • 3,736 posts

Posted 23 November 2014 - 05:49 AM

Abstract

The objective of this study was to determine whether the rabbit was a suitable model to test new synthetic androgens for potential liver toxicity within a short dosing interval.

...

Hence, the rabbit appears to be a promising model for detection of potential liver toxicity by synthetic androgens using BSP clearance and serum liver enzyme levels as early indicators of injury.

 

http://www.ncbi.nlm....pubmed/20378929

 

Harry Lennon could have told them that 45 years ago.

http://www.ncbi.nlm..../pubmed/5922195

http://www.ncbi.nlm..../pubmed/5902172


  • Majora23 likes this

330tqur.jpg





0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users