Essentially, the determining factor in RD is the "size" of the compound, so no, it wouldn't be irrelevant. Particles small enough to pass through the skin =useful, putting a product through a process that guarantees said product is as small as can be = very useful.
Oh is that how it works?
I don't think you are understanding this. Nano technology is specifically designed for oral use. It's in its own liquid carrier that I'm pretty darn skeptical would permeate the skin if rubbed on.
I've messed with TD compounds more than most. Doesn't make me the foremost expert on it but, to date, nano technology has absolutely no implications on TD application. They are completely different sciences geared for different purposes.
That'd be fantastic if "nano" technology split the MW of this or that compound, in powder form, to such a small size it could effectively permeate the skin at 60-70-80% but it's not some it's not some attempt at fission you can then drop the split material into a TD solution for TD use.